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LMP-1 (Epstein-Barr Virus) Monoclonal Antibody
Mouse Monoclonal CS1, CS2, CS3, CS4 IgG1
Mob194-01
100 µL
Liquid
IHC
Epstein-Barr Virus
Mouse
Shipping info:
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Product Details
Anti-LMP-1 (Epstein-Barr Virus) (MOUSE) Monoclonal Antibody - Mob194-01
Epstein-Barr Virus, EBV, Latent Membrane Protein 1, Human herpesvirus 4, HHV-4
Mouse
Monoclonal
CCS
Target Details
EBV
Epstein-Barr Virus
Recombinant Protein
Anti-LMP-1 (Epstein-Barr Virus) antibody was produced in mice by repeated immunizations with recombinant fusion protein containing sequences of bacterial β-galactosidase and EBV encoded latent membrane protein.
The antibody was clarified from tissue culture supernatant. This antibody is specific to 60 kDa latent membrane protein (LMP-1) encoded by the BNLF1 gene of the EBV. Each clone reacts with different epitopes on the hydrophilic C-terminus of the cytoplasmic domain of LMP-1.
Application Details
IHC
Anti-LMP-1 (Epstein-Barr Virus) (MOUSE) Monoclonal Antibody was tested in IHC-P with positive control infected lymphoblastoma, Hodgkin’s lymphoma tissues. Cellular Localization: Cytoplasmic. The user is advised to validate the use of the products with their tissue specimens prepared and handled in accordance with their laboratory practices. This antibody stains strongly with EBV positive lymphoblastoid cell lines and EBV infected B cell immunoblasts in infectious mononucleosis. Consult references (Kiernan, 1981: Sheehan & Hrapchak, 1980) for further details on specimen preparation.
Formulation
0.01% (w/v) Sodium Azide
Shipping & Handling
Wet Ice
Store at 2-8°C. This antibody is suitable for use until the expiration date when stored at 2-8°C. Do not use product after the expiration date printed on vial. If reagents are stored under conditions other than those specified here, they must be verified by the user. Diluted reagents should be used promptly. Unused portions of antibody preparation should be discarded after one day. The presence of precipitate or an unusual odor indicates that the antibody is deteriorating and should not be used.
Latent membrane protein 1 acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. It functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. It interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, LMP1 induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.