ModDetect™ Panels
ModDetect™ Panels
ModDetect™ panels (patent pending) are designed to facilitate the detection of specific chemical modifications independent of the sequence or location of the modification and can be used to evaluate a variety of RNA Tx modalities and nucleic acid structures. The universal nature and unique specificity and sensitivity of these reagents eliminates the need for unique probes and accelerates candidate triage for a cost-effective, low-risk solution that can save 9-12 months in drug development.
Available Panels
About the ModDetect™ Panels
- Includes 5 reagents reagents for testing and selection based on performance with client drug
- Designed for use in various immunoassays, such as ELISA, IF, and IHC
- Includes 3 secondary antibodies or 3 streptavidin reporter reagents
- Unconjugated and biotin-conjugated panels available
Explore the Performance of Our PS, 2’-MOE, and 2’-OMe Panels
Localization and Quantification of Oligonucleotide Therapeutic Drugs: Immunoassays Specific for Nucleic Acid Modifications Independent of Sequence
Todd Giardiello, Amy Anderson, Christine E. Dry, Seth A. Farrier, and Carl A. Ascoli
Request Access to Poster
Targeted RNA Therapeutic Modalities
ModDetect™ panels are designed to facilitate the detection of specific chemical modifications independent of the sequence or location of the modification and can be used to evaluate a variety of RNA Tx modalities and nucleic acid structures.
Antisense Oligonucleotides (ASO)
Small interfering RNA (siRNA) 
Micro RNA (miRNA)
Aptamers
Single-Stranded RNA 
Double-Stranded RNA 
DNA-RNA Hybrids
RNA-DNA Heterosubstrate (Gapmer)
ModDetect™ Panels as Analytical Tools
The ModDetect™ panels serve as analytical tools against different types of nucleic acid targets including modified backbones and 2’-O ribose moieties. Our in-house development ensures supply chain security and respect of client confidentiality and intellectual property.
Versatile Applications Across Diverse Therapeutic Products
Time Saving
Save 9-12 months in drug development with faster candidate triage
Less Risk
Evaluate multiple uniquely-specific reagents simultaneously in various immunoassays
Cost Saving
Eliminate the need for custom antibody development
Hear From Our Customers
“Rockland’s PS03, PS04, and PS05 antibodies work beautifully for detecting 2’MOE or cEt gapmer ASOs in the endocytic pathway, offering a low background and a strong, specific signal. PS05 is probably our first choice for this application because it works well even when diluted >1:1,000. For each of these antibodies, signal strength is proportional to the number of PS nucleotides in the oligo, as would be expected.“
Aimee Edinger, VMD/PhD
Professor, Developmental and Cell Biology, UC Irvine
Interested in our ModDetect™ product line?
We can help move your program forward—contact us to find out how.